Target alternative vaccine safety testing strategies for pertussis toxin
نویسندگان
چکیده
منابع مشابه
Alternative Safety Testing Strategies for Acellular Pertussis Vaccines
77 Infection by the Gram-negative bacterium Bordetella pertussis can lead to the development of pertussis, also known as whooping cough due to the characteristic sound infected infants make following a severe coughing fit. Infection by B. pertussis is fairly common, but it rarely causes serious complications in adults. However, the infection can be fatal in infants and young children if left un...
متن کاملPertussis toxin is required for pertussis vaccine encephalopathy.
A mouse model for encephalopathy induced by pertussis immunization has been described; it has features that closely resemble some of the severe reactions, including seizures and a shock-like state leading to death, occasionally seen after administration of Bordetella pertussis (whooping cough) vaccine. Susceptibility to encephalopathy maps to genes of the major histocompatibility complex and co...
متن کاملPertussis Vaccine Testing for Freedom-from-toxicity.
The results of 9.5 years of official testing of vaccines containing pertussis vaccine, plain or adsorbed with alum, Al(OH)(3), or AlPO(4), are reported. Toxicity was evaluated by weight changes in mice at 3 and 7 days after injection and intercurrent deaths. Toxicity was encountered during the early use of AlPO(4) in pertussis vaccine products, with a special product and quadruple-antigen vacci...
متن کاملHighly sensitive histamine-sensitization test for residual activity of pertussis toxin in acellular pertussis vaccine.
Histamine-sensitization test method based on histamine-sensitizing death is widely used for controlling residual activity of pertussis toxin in acellular pertussis vaccines. The test method evaluates the residual activity according to the death of mice injected with a test vaccine after histamine challenge and the test result, therefore, depends on the sensitivity of mice. A highly sensitive te...
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Cervical cancer, caused by Human Papillomavirus (HPV) is the third largest cause of female mortality over the world with an estimated 500,000 cases and 270,000 deaths annually [1]. Nevertheless there are only two vaccines are available in the world market to protect cervical cancer. Gardasil® (Merck, USA)) and Cervarix® (GlaxoSmithKline, UK) are both Virus Like Particle (VLP) based vaccines and...
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ژورنال
عنوان ژورنال: Procedia in Vaccinology
سال: 2011
ISSN: 1877-282X
DOI: 10.1016/j.provac.2011.10.026